Essential Role ofBRCA2in Ovarian Development and Function
نویسندگان
چکیده
منابع مشابه
Molecular basis of ovarian development and function.
Molecular biology, and in particular the ability to modify genetic composition in vivo through transgenesis, has revolutionized the study of reproductive biology. Knowledge of the mechanisms of oocyte growth and hormone action have benefited from the identification and characterization of several novel genes involved in ovarian development and function. There are hundreds of genetically altered...
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In mammals, female development has traditionally been considered a default process in the absence of the testis-determining gene, Sry. Recently, it has been documented that the gene for R-spondin1 (RSPO1), a novel class of soluble activator for Wnt/beta-catenin signaling, is mutated in two Italian families with female-to-male (XX) sex reversal. To elucidate the role of Rspo1 as a candidate fema...
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chapter one is devoted to a moderate discussion on preliminaries, according to our requirements. chapter two which is based on our work in (24) is devoted introducting weighted semigroups (s, w), and studying some famous function spaces on them, especially the relations between go (s, w) and other function speces are invesigated. in fact this chapter is a complement to (32). one of the main fea...
15 صفحه اولOVARIAN DEVELOPMENT, FUNCTION, AND GRANULOSA CELL TUMORIGENESIS: Role of GATA Transcription Factors and Anti-Müllerian Hormone
.............................................................................................................................. 6 LIST OF ORIGINAL PUBLICATIONS ..................................................................................... 8 ABBREVIATIONS .................................................................................................................... 9 INTRODUCTION .......
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The mammary gland is a dynamic organ that undergoes cyclic developmental and regressive changes during the lifetime of a female mammal. Mammogenesis begins during embryonic life with the development of the first mammary gland rudiments and ductal system. After birth, during the pre-pubertal period, the ductal growth of the mammary parenchyma occurs through the fat pad. In most of the ruminant s...
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ژورنال
عنوان ژورنال: New England Journal of Medicine
سال: 2018
ISSN: 0028-4793,1533-4406
DOI: 10.1056/nejmoa1800024